Peptivoice

Sermorelin reconstitution calculator

GHRH(1-29) - formerly Geref®

Sermorelin is the first 29 amino acids of natural GHRH - the fragment that carries full activity. Uniquely among clinic peptides, it was an actual FDA-approved drug for over a decade, which is why anti-aging medicine standardized on it and why it survived the compounding crackdowns better than ipamorelin or CJC-1295.

Regulatory status (August 2026). Formerly FDA-approved (Geref, for pediatric growth-hormone deficiency); the brand was discontinued in 2008 for commercial - not safety - reasons. That approval history is why sermorelin persists in compounding channels, in a lane far more defensible than Category 2 peptides, though still contested post-2023 tightening.
Reconstitution · Sermorelinmath only - no dosing advice
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Enter vial size, water volume, and the dose your provider gave you.

This tool converts the numbers you enter (dose ÷ concentration = volume). It never suggests a dose. The FDA has documented hospitalizations caused by mg / ml / unit conversion errors with vial-and-syringe products - if the readout surprises you, stop and verify with your prescriber or pharmacist.

Questions people actually search

Is sermorelin legal?

It occupies the most defensible position of the GH-axis peptides: a formerly approved drug (Geref), discontinued commercially, still produced by some US compounding pharmacies under physician prescription. That lane has narrowed since 2023 but is categorically different from Category 2 peptides like ipamorelin.

How many units is 300 mcg of sermorelin?

Depends on your vial: a 5 mg vial with 2 ml of bacteriostatic water is 2.5 mg/ml, so 300 mcg = 0.12 ml = 12 units. Compounded vials vary widely (2-15 mg), so always compute from your label.

Sermorelin vs ipamorelin - which is 'better'?

They hit different receptors: sermorelin mimics GHRH; ipamorelin mimics ghrelin. Clinics historically stacked them. The practical 2026 difference is regulatory: sermorelin retains a prescription compounding lane; ipamorelin (FDA Category 2) does not.

Read the full reconstitution guide →