Peptivoice

Sermorelin reconstitution calculator

GHRH(1-29) - formerly Geref®

Sermorelin is the first 29 amino acids of natural GHRH - the fragment that carries full activity. Uniquely among clinic peptides, it was an actual FDA-approved drug for over a decade, which is why anti-aging medicine standardized on it and why it survived the compounding crackdowns better than ipamorelin or CJC-1295.

Regulatory status (August 2026). Formerly FDA-approved (Geref, for pediatric growth-hormone deficiency); the brand was discontinued in 2008 for commercial - not safety - reasons. That approval history is why sermorelin persists in compounding channels, in a lane far more defensible than Category 2 peptides, though still contested post-2023 tightening.
Reconstitution · Sermorelinmath only, no dosing advice
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Enter vial size, water volume, and the dose your provider gave you.

This tool converts the numbers you enter (dose ÷ concentration = volume). It never suggests a dose. The FDA has documented hospitalizations caused by mg / ml / unit conversion errors with vial-and-syringe products. If the readout surprises you, stop and verify with your prescriber or pharmacist.

Questions people actually search

Is sermorelin legal?

It occupies the most defensible position of the GH-axis peptides: a formerly approved drug (Geref), discontinued commercially, still produced by some US compounding pharmacies under physician prescription. That lane has narrowed since 2023 but is categorically different from Category 2 peptides like ipamorelin.

How many units is 300 mcg of sermorelin?

Depends on your vial: a 5 mg vial with 2 ml of bacteriostatic water is 2.5 mg/ml, so 300 mcg = 0.12 ml = 12 units. Compounded vials vary widely (2-15 mg), so always compute from your label.

Sermorelin vs ipamorelin - which is 'better'?

They hit different receptors: sermorelin mimics GHRH; ipamorelin mimics ghrelin. Clinics historically stacked them. The practical 2026 difference is regulatory: sermorelin retains a prescription compounding lane; ipamorelin (FDA Category 2) does not.

Read the full reconstitution guide →